Paper Nr: |
1 |
Title: |
Optogentics and Optrode Technology to Brain Function Manupulation |
Authors: |
Mohammad Ismail Zibaii, Leila Dargahi, Abdolaziz Ronaghi, Farshad Abedzadeh, Sareh Pandamoz, Saied Salehi, Zahra Fatahi, Abbas Haghparast and Hamid Latifi |
Abstract: |
Optogenetics comprises a growing family of related techniques for the optical interrogation and control of excitable cells. Combining genetic targeting with light delivery systems makes it possible to drive or silence subpopulations of neurons and the related behaviours, with a high spatiotemporal precision. Since optical manipulation is fast, selective, and minimally invasive, it provides distinct advantages over traditional electrical means or pharmacological approaches for cell perturbation. Here we showed in anesthetized rat that optogenetic stimulation of nucleus accumbens (NAc) neurons increased neural activation. We labelled a population of neurons activated with channelrhodopsin-2 (ChR2) and later optically stimulated these neurons by using an optrode and recorded spontaneous action potentials from the one neuron. |
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Paper Nr: |
4 |
Title: |
Manufacturing and Optimization of Sol-gel-based TiO2-SiO2 thin Films as High Refractive Index Overlays for Long Period Grating-based Biosensing |
Authors: |
Palas Biswas, Francesco Chiavaioli, Sunirmal Jana, Somnath Bandyopadhyay, Nandini Basumallick, Ambra Giannetti, Sara Tombelli, Susanta Bera, Aparajita Mallick, Francesco Baldini and Cosimo Trono |
Abstract: |
The manufacturing procedure and the optimization of high refractive index overlays for long period grating-based sensors are reported. The overlay consists of a sol-gel-based TiO2-SiO2 thin film. By carefully tuning the overlay thickness and refractive index, it is possible to bring the LPG in the so-called transition mode working region, and to optimize and maximize the LPG sensing performances. LPGs are here characterized as optical refractometers, and, after a suitable functionalization of the sol-gel coated fiber surface, as biosensors performing an IgG/anti-IgG bioassay. |
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